Scnn1g Gene Summary [Rat]
Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in several processes, including intracellular sodium ion homeostasis; sodium ion import across plasma membrane; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scnn1g |
| Official Name | sodium channel epithelial 1 gamma subunit [Source:RGD Symbol;Acc:3641] |
| Ensembl ID | ENSRNOG00000017842 |
| Bio databases IDs | |
| Aliases | sodium channel epithelial 1 gamma subunit |
| Synonyms | BESC3, ENaC, ENaCg, ENaC gamma, ENaC γ, epithelial sodium channel, γ subunit, gamma ENAC, LDLS2, PHA1, PHA1B3, SCNEG, sodium channel epithelial 1 subunit gamma, sodium channel epithelial 1 subunit γ, sodium channel, nonvoltage-gated 1 gamma, sodium channel, nonvoltage-gated 1 γ, γ ENAC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scnn1g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium channel
- PPXY motif
- sodium ion transporter
- amiloride-sensitive sodium channel
- WW domain binding
- PPPXY motif
- protein binding
- thumb domain
- proline tyrosine motif
- ion channel
- degenerin
- ubiquitin binding domain
- sodium channel transporter
Pathways
Biological processes and signaling networks where the Scnn1g gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- coronary disease
- disorder of coronary artery
- heart failure
- essential hypertension
- chronic kidney disease
- colorectal cancer
- heart disease
- Liddle syndrome type 2
- bronchiectasis type 3
role in cell
- activation in
- molecular cleavage in
- whole-cell conductance
- migration by
- response by
- healing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- nucleoplasm
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scnn1g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- multicellular organismal water homeostasis
- sensory perception of sour taste
- sodium ion homeostasis
- cellular response to acidity
- cellular sodium ion homeostasis
- sensory perception of salty taste
- sodium ion transmembrane transport
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- sodium channel complex
- extracellular vesicular exosome
- external side of plasma membrane
- apical plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- protein binding
- sodium channel activity
- ligand-gated sodium channel activity
- WW domain binding