Kcnj1 Gene Summary [Rat]
Enables several functions, including ATP-activated inward rectifier potassium channel activity; anion binding activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion import across plasma membrane; and response to potassium ion. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj1 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 1 [Source:RGD Symbol;Acc:2957] |
| Ensembl ID | ENSRNOG00000059005 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 1 |
| Synonyms | 70-pS, 70ps K+ channel, KAB-1, Kcnj, Kcnj1 v1, Kcnj1 v3, KIR1.1, LOC100910423, potassium inwardly rectifying channel subfamily J member 1, potassium inwardly-rectifying channel, subfamily J, member 1, ROMK, ROMK1, ROMK2, ROMK3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- peptide binding
- inward rectifier potassium channel
- cytoplasmic domain
- Inward rectifier potassium channel C-terminal domain
- phosphatidylinositol-4,5-bisphosphate binding
- Inward rectifier potassium channel transmembrane domain
- ATP-activated inward rectifier potassium channel
- ATP binding
- metal ion binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnj1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- stroke
- disorder of coronary artery
- Bartter syndrome type 2
- Bartter syndrome
- polyuria
- myocardial infarction
- growth failure
- polycystic kidney disease
regulates
- Na+
- K+
- KCNA
- phosphate
- KCNJ1
- chloride
- hormone
- sodium chloride
role in cell
- apoptosis
- proliferation
- response by
- silencing
- discharge
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- ATP binding
- inward rectifier potassium channel activity
- ATP-activated inward rectifier potassium channel activity