Sgk1 Gene Summary [Rat]
Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including learning or memory; negative regulation of microtubule polymerization; and positive regulation of dendrite morphogenesis. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgk1 |
| Official Name | serum/glucocorticoid regulated kinase 1 [Source:RGD Symbol;Acc:3668] |
| Ensembl ID | ENSRNOG00000011815 |
| Bio databases IDs | |
| Aliases | serum/glucocorticoid regulated kinase 1 |
| Synonyms | serum/glucocorticoid regulated kinase 1, Serum/Glucocorticoid Regulated Serine/Threonine Protein Kinase, SGK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- protein threonine/tyrosine kinase
- Protein kinase domain
- activation loop
- Extension to Ser/Thr-type protein kinases
- tau protein binding
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein kinase C terminal domain
- catalytic domain
- PPXY motif
- Protein tyrosine and serine/threonine kinase
- potassium channel regulator
- nuclear localization sequence
- sodium channel regulator
- protein binding
- chloride channel regulator
- proline tyrosine motif
- calcium channel regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Sgk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- female infertility
- schizophrenia
- dementia
- prostate cancer
- prostatic carcinoma
- epithelial cancer
- Huntington disease
- Alzheimer disease
- hyperalgesia
- plasma cell myeloma
role in cell
- activation in
- cell death
- expression in
- apoptosis
- proliferation
- migration
- growth
- survival
- phosphorylation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- apical cell surfaces
- apical membrane
- nucleoplasm
- nuclear speckles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of gastric acid secretion
- neuron projection morphogenesis
- regulation of apoptotic process
- protein phosphorylation
- response to DNA damage stimulus
- regulation of blood pressure
- regulation of cell proliferation
- regulation of sequence-specific DNA binding transcription factor activity
- renal sodium ion absorption
- long-term memory
- sodium ion transport
- regulation of cell growth
- apoptotic process
- regulation of catalytic activity
- positive regulation of transporter activity
- regulation of cell migration
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- ATP binding
- chloride channel regulator activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- calcium channel regulator activity
- protein serine/threonine kinase activity
- potassium channel regulator activity