Apbb1 Gene Summary [Rat]
Enables DNA-binding transcription factor binding activity; amyloid-beta binding activity; and tau protein binding activity. Involved in several processes, including DNA repair-dependent chromatin remodeling; negative regulation of cell cycle G1/S phase transition; and regulation of transcription by RNA polymerase II. Located in several cellular components, including axon; dendritic spine; and synaptic membrane. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse; postsynaptic density; and presynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease and nicotine dependence. Orthologous to human APBB1 (amyloid beta precursor protein binding family B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apbb1 |
| Official Name | amyloid beta precursor protein binding family B member 1 [Source:RGD Symbol;Acc:2122] |
| Ensembl ID | ENSRNOG00000018020 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor protein binding family B member 1 |
| Synonyms | amyloid beta precursor protein binding family B member 1, AMYLOID precursor protein-binding family B, amyloid β precursor protein binding family B member 1, FE65, MGC:9072, RIR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apbb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein interaction domain
- histone binding
- transcription regulator
- transcription co-activator
- transcription factor binding
- chromatin binding
- low-density lipoprotein receptor binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- beta-amyloid binding
- WW domain
- Domain with 2 conserved Trp (W) residues
- binding protein
- tau protein binding
- ligand-binding domain
- WW
Pathways
Biological processes and signaling networks where the Apbb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- Alzheimer disease
- Parkinson disease
role in cell
- quantity
- apoptosis
- outgrowth
- cell death
- activation in
- expression in
- differentiation
- formation
- growth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- perinuclear membrane
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- actin filaments
- cytosol
- presynaptic membrane
- postsynaptic membrane
- nucleoplasm
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- synaptosomes
- synapse
- filopodia
- perikaryon
- postsynaptic density
- presynaptic terminals
- axonal shafts
- lamellipodia
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apbb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- smooth muscle contraction
- positive regulation of transcription, DNA-dependent
- axonogenesis
- apoptotic process
- positive regulation of apoptotic process
- positive regulation of neuron projection development
- positive regulation of protein secretion
Cellular Component
Where in the cell the gene product is active
- growth cone
- nucleus
- cytoplasm
- nuclear speck
- endoplasmic reticulum
- synapse
- plasma membrane
- lamellipodium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- ubiquitin protein ligase binding
- low-density lipoprotein particle receptor binding
- protein binding
- transcription coactivator activity
- histone binding
- transcription factor binding
- chromatin binding
- beta-amyloid binding
- binding, bridging