Vps33a Gene Summary [Rat]
Predicted to be involved in several processes, including autophagosome maturation; melanosome localization; and regulation of lysosomal lumen pH. Predicted to act upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Predicted to be located in autophagosome; endosome; and perinuclear region of cytoplasm. Predicted to be part of several cellular components, including AP-3 adaptor complex; CORVET complex; and clathrin complex. Predicted to be active in lysosome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps33a |
| Official Name | VPS33A core subunit of CORVET and HOPS complexes [Source:RGD Symbol;Acc:620643] |
| Ensembl ID | ENSRNOG00000056889 |
| Bio databases IDs | |
| Aliases | VPS33A core subunit of CORVET and HOPS complexes |
| Synonyms | 3830421M04Rik, AC048338.1, bf, Diablo, MPSPS, r-Vps33a, VPS33A core subunit of CORVET and HOPS complexes, VPS33A CORVET/HOPS core subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps33a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- Sec1 family
- transporter
Pathways
Biological processes and signaling networks where the Vps33a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mucopolysaccharidosis-plus syndrome
- soft tissue sarcoma
- soft tissue sarcoma cancer
- Duchenne muscular dystrophy
role in cell
- cell death
- formation
- fusion
- localization
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- lysosome
- endosomal membrane
- autophagic vacuoles
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps33a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- vesicle-mediated transport
- regulation of SNARE complex assembly
- regulation of lysosomal lumen pH
- platelet formation
- regulation of developmental pigmentation
- melanosome localization
- endosome to lysosome transport
- endosomal vesicle fusion
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- CORVET complex
- late endosome
- autophagic vacuole
- lysosomal membrane
- lysosome
- late endosome membrane
- early endosome
- perinuclear region of cytoplasm
- endosome membrane
- AP-3 adaptor complex
- clathrin-coated vesicle
- clathrin complex
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding