Sag Gene Summary [Rat]
Enables spectrin binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; retinitis pigmentosa; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual arrestin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sag |
| Official Name | S-antigen visual arrestin [Source:RGD Symbol;Acc:3619] |
| Ensembl ID | ENSRNOG00000018185 |
| Bio databases IDs | |
| Aliases | S-antigen visual arrestin |
| Synonyms | A930001K18Rik, Arr1, arrestin, DKFZP686J1593, Irbp, LOC683311, RETSAG, ROD ARRESTIN, RP47, RP96, SAGMR, SANTI, S-ANTIGEN, S-antigen, retina and pineal gland (arrestin), S-antigen visual arrestin, VISUAL ARRESTIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sag often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- Arrestin (or S-antigen), C-terminal domain
- spectrin binding
- phosphoprotein binding
- protein binding
- Arrestin (or S-antigen), N-terminal domain
Pathways
Biological processes and signaling networks where the Sag gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pancreatic carcinoma
- Huntington disease
- Oguchi disease type 1
- spinocerebellar ataxia type 7
- oguchi disease type 2
- Oguchi disease
- cone dystrophy
- systemic lupus erythematosus
- retinitis pigmentosa type 96
role in cell
- migration
- electrophysiology
- abnormal morphology
- upregulation in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sag gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhodopsin mediated signaling pathway
- cell surface receptor signaling pathway
- G-protein coupled receptor internalization
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- photoreceptor inner segment
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- G-protein coupled receptor binding
- protein binding
- phosphoprotein binding
- opsin binding