Slc17a7 Gene Summary [Rat]
Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; and sodium-dependent phosphate transport. Located in excitatory synapse and presynaptic active zone. Is active in synaptic vesicle membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Orthologous to human SLC17A7 (solute carrier family 17 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc17a7 |
| Official Name | solute carrier family 17 member 7 [Source:RGD Symbol;Acc:620101] |
| Ensembl ID | ENSRNOG00000020650 |
| Bio databases IDs | |
| Aliases | solute carrier family 17 member 7 |
| Synonyms | 2900052E22RIK, BNPI, GVT1, solute carrier family 17 member 7, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, VGLUT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc17a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- Major Facilitator Superfamily
- potassium:hydrogen antiporter
- Na(+)-dependent inorganic phosphate cotransporter
- protein binding
- phosphoglycerate transporter family protein
- inorganic phosphate transporter
- glutamate transporter
- glutamate-gated chloride channel
- chloride channel
- sodium:phosphate symporter
- uniporter
- transporter
Pathways
Biological processes and signaling networks where the Slc17a7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- Huntington disease
- schizophrenia
- blindness
- growth failure
- streptozotocin induced type1 diabetes
role in cell
- expression in
- accumulation in
- morphology
- abnormal morphology
- response
- synaptic transmission
- acidification in
- development
- endocytosis
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
- vesicles
- dendritic spines
- synaptic vesicles
- nerve ending
- synapse
- rod spherules
- photoreceptor outer segments
- transport vesicles
- dense-core vesicles
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
- axon terminals
- mossy fiber boutons
- presynaptic terminals
- excitatory synapses
- clathrin-coated vesicles
- transcytotic vesicle
- parallel fiber
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc17a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate ion homeostasis
- potassium ion transmembrane transport
- regulation of synaptic vesicle endocytosis
- anion transport
- chloride transport
- potassium ion transport
- neurotransmitter transport
- ion transport
- phosphate ion transport
- neural retina development
- sodium-dependent phosphate transport
- regulation of synapse structure and activity
- sodium ion transmembrane transport
- L-glutamate transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- presynaptic active zone
- excitatory synapse
- membrane
- synaptic vesicle membrane
- neuron projection
- clathrin sculpted glutamate transport vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- sodium:phosphate symporter activity
- potassium:hydrogen antiporter activity
- chloride channel activity
- L-glutamate transmembrane transporter activity