Shtn1 Gene Summary [Rat]
Enables actin filament binding activity and cell adhesion molecule binding activity. Involved in several processes, including actin filament bundle retrograde transport; netrin-activated signaling pathway; and small GTPase-mediated signal transduction. Acts upstream of or within axonogenesis. Located in axonal growth cone; filopodium; and lamellipodium. Orthologous to human SHTN1 (shootin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shtn1 |
| Official Name | shootin 1 [Source:RGD Symbol;Acc:1311558] |
| Ensembl ID | ENSRNOG00000018350 |
| Bio databases IDs | |
| Aliases | shootin 1 |
| Synonyms | 4930506M07Rik, KIAA1598, mKIAA1598, RGD1311558, Shootin-1, SHOT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Shtn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- cell adhesion molecule binding
- protein binding
- identical protein binding
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- preeclampsia
- cleft lip
- heart failure
- cleft palate
- glioblastoma
- glioblastoma cancer
- cleft palate with cleft lip
- cannabis dependence
- orofacial cleft
regulates
- phosphatidylinositol-3,4,5-triphosphate
- G-actin (family)
role in cell
- accumulation in
- length
- transition
- depolarization
- morphogenesis
- formation
- migration by
- development
- extension
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- axon component
- Cytoplasm
- perinuclear region
- microtubules
- cytosol
- growth cone
- neuritic shafts
- membrane processes
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Shtn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum polarization
- axonogenesis
- neuron projection morphogenesis
- cytoplasmic actin-based contraction involved in cell motility
- Cdc42 protein signal transduction
- Ras protein signal transduction
- positive regulation of axon extension
- substrate-dependent cell migration, cell extension
- netrin-activated signaling pathway
- positive regulation of neuron migration
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell leading edge
- perikaryon
- microtubule associated complex
- microtubule
- growth cone
- perinuclear region of cytoplasm
- axonal growth cone
- cytoplasm
- filopodium
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding
- kinesin binding