Slc22a7 Gene Summary [Rat]
Enables prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in prostaglandin transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a7 |
| Official Name | solute carrier family 22 member 7 [Source:RGD Symbol;Acc:621699] |
| Ensembl ID | ENSRNOG00000018420 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 7 |
| Synonyms | hOAT11, Livtr, Lstp, NLT, OAT2, rOAT2, solute carrier family 22 member 7, solute carrier family 22 (organic anion transporter), member 7, Ti-Lpt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- Multidrug resistance protein
- phosphate:H+ symporter
- protein binding
- alpha-ketoglutarate transporter
- organic anion transporter
- prostaglandin transporter
- Sugar (and other) transporter
- cation transport protein
- transporter
Pathways
Biological processes and signaling networks where the Slc22a7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- hearing loss
- tinnitus
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- alloxan-induced diabetic nephropathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
regulates
- lipid
- 2-oxoglutaric acid
- L-glutamic acid
- dinoprost
- salicylic acid
- xenobiotic
- ketoprofen
- indomethacin
- organic anion
- prostaglandin
role in cell
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- ion transport
- transmembrane transport
- xenobiotic metabolic process
- organic anion transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- organic anion transmembrane transporter activity
- alpha-ketoglutarate transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity