Rxrg Gene Summary [Rat]
Predicted to enable molecular condensate scaffold activity; nuclear receptor activity; and retinoic acid-responsive element binding activity. Involved in several processes, including nervous system development; regulation of myelination; and response to retinoic acid. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rxrg |
| Official Name | retinoid X receptor gamma [Source:RGD Symbol;Acc:620046] |
| Ensembl ID | ENSRNOG00000004537 |
| Bio databases IDs | |
| Aliases | retinoid X receptor gamma |
| Synonyms | LOC102553986, NR2B3, retinoid X receptor gamma, retinoid X receptor γ, RXRC, RXR-gamma, RXR-γ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rxrg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- protein binding activity, bridging
- alpha helix
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- Nuclear/hormone receptor activator site AF-1
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the Rxrg gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Aryl Hydrocarbon Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Glucocorticoid Receptor Signaling
- LXR/RXR Activation
- Non-Small Cell Lung Cancer Signaling
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Small Cell Lung Cancer Signaling
- TR/RXR Activation
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acne vulgaris
- obesity
- Huntington disease
- schizophrenia
- bipolar disorder
- leukemia
- myelodysplastic syndrome
- type M3 acute myeloid leukemia
- alopecia areata
- HIV infection
role in cell
- expression in
- phosphorylation in
- quantity
- number
- survival
- transactivation in
- development
- invasiveness
- myelination
- elimination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rxrg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoic acid receptor signaling pathway
- response to retinoic acid
- cell differentiation
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- retinoic acid-responsive element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity