SLC22A7 Gene Summary [Human]
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | SLC22A7 |
| Official Name | solute carrier family 22 member 7 [Source:HGNC Symbol;Acc:HGNC:10971] |
| Ensembl ID | ENSG00000137204 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 7 |
| Synonyms | hOAT11, Livtr, Lstp, NLT, OAT2, rOAT2, solute carrier family 22 member 7, solute carrier family 22 (organic anion transporter), member 7, Ti-Lpt |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- Multidrug resistance protein
- phosphate:H+ symporter
- protein binding
- alpha-ketoglutarate transporter
- organic anion transporter
- prostaglandin transporter
- Sugar (and other) transporter
- cation transport protein
- transporter
Pathways
Biological processes and signaling networks where the SLC22A7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- hearing loss
- tinnitus
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- alloxan-induced diabetic nephropathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
regulates
- lipid
- 2-oxoglutaric acid
- L-glutamic acid
- dinoprost
- salicylic acid
- xenobiotic
- ketoprofen
- indomethacin
- organic anion
- prostaglandin
role in cell
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- ion transport
- transmembrane transport
- xenobiotic metabolic process
- organic anion transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- organic anion transmembrane transporter activity
- alpha-ketoglutarate transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity