LOC100359583 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor binding activity; histone binding activity; and histone chaperone activity. Involved in positive regulation of NF-kappaB transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100359583 |
| Official Name | hypothetical protein LOC100359583 [Source:RGD Symbol;Acc:2323611] |
| Ensembl ID | ENSRNOG00000018584 |
| Bio databases IDs | |
| Aliases | hypothetical protein LOC100359583 |
| Synonyms | alpha PROTHYMOSIN, prothymosin alpha, Prothymosin-α, Thym, TMSA, α PROTHYMOSIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100359583 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Prothymosin/parathymosin family
- nuclear localization sequence
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- collagen-induced arthritis
- polyarticular juvenile rheumatoid arthritis
- aortic valve calcification
- colon epithelial cancer
- colon carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- formation
- necrosis
- growth
- differentiation
- maturation
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100359583 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding