PTMA Gene Summary [Human]
Enables DNA-binding transcription factor binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PTMA |
| Official Name | prothymosin alpha [Source:HGNC Symbol;Acc:HGNC:9623] |
| Ensembl ID | ENSG00000187514 |
| Bio databases IDs | |
| Aliases | prothymosin alpha, gene sequence 28, prothymosin-α |
| Synonyms | alpha PROTHYMOSIN, prothymosin alpha, Prothymosin-α, Thym, TMSA, α PROTHYMOSIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTMA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Prothymosin/parathymosin family
- nuclear localization sequence
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- collagen-induced arthritis
- polyarticular juvenile rheumatoid arthritis
- aortic valve calcification
- colon epithelial cancer
- colon carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- formation
- necrosis
- growth
- differentiation
- maturation
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTMA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding