Ptma Gene Summary [Mouse]
Enables histone binding activity and histone chaperone activity. Involved in chromatin organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; extraembryonic component; and genitourinary system. Used to study polycystic kidney disease and pulmonary emphysema. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptma |
| Official Name | prothymosin alpha [Source:MGI Symbol;Acc:MGI:97803] |
| Ensembl ID | ENSMUSG00000026238 |
| Bio databases IDs | |
| Aliases | prothymosin alpha |
| Synonyms | alpha PROTHYMOSIN, prothymosin alpha, Prothymosin-α, Thym, TMSA, α PROTHYMOSIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Prothymosin/parathymosin family
- nuclear localization sequence
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- collagen-induced arthritis
- polyarticular juvenile rheumatoid arthritis
- aortic valve calcification
- colon epithelial cancer
- colon carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- formation
- necrosis
- growth
- differentiation
- maturation
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding