Sumo3 Gene Summary [Rat]
Predicted to enable SUMO transferase activity; protein tag activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in protein sumoylation and regulation of protein localization to nucleus. Predicted to act upstream of or within positive regulation of ubiquitin-dependent protein catabolic process and protein localization to nucleus. Predicted to be located in PML body. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human SUMO3 (small ubiquitin like modifier 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sumo3 |
| Official Name | small ubiquitin-like modifier 3 [Source:RGD Symbol;Acc:1561022] |
| Ensembl ID | ENSRNOG00000038489 |
| Bio databases IDs | |
| Aliases | small ubiquitin-like modifier 3 |
| Synonyms | 2810014B19Rik, AA409334, D10Ertd345e, small ubiquitin-like modifier 3, SMT3A, Smt3B, SMT3H1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sumo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
- surface domain
Pathways
Biological processes and signaling networks where the Sumo3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- thyroid cancer
- gastric cancer
- breast cancer
- Down syndrome
- hepatocellular dysplasia
- bipolar disorder
- Crohn disease
- asthma
- cardiomyopathy
role in cell
- binding in
- proliferation
- invasion
- expression in
- apoptosis
- phosphorylation in
- activation in
- growth
- generation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- glutaminergic synapse
- Cytoplasm
- nuclear foci
- sister chromatids
- nucleoplasm
- nucleoli
- nuclear bodies
- XY bodies
- PML nuclear bodies
- mitotic spindle
- kinetochores
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sumo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of DNA binding
- protein sumoylation
- regulation of protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tag
- small conjugating protein ligase binding