Pax8 Gene Summary [Rat]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pax8 |
| Official Name | paired box 8 [Source:RGD Symbol;Acc:620434] |
| Ensembl ID | ENSRNOG00000026203 |
| Bio databases IDs | |
| Aliases | paired box 8 |
| Synonyms | paired box 8, Paired box gene 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pax8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- HTH_ARSR
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- HTH_CRP
- Paired-box protein 2 C terminal
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- 'Paired box' domain
- transcription factor activity
- Paired Box domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- insomnia
- epithelial cancer
- follicular papillary thyroid carcinoma
- mixed papillary and follicular thyroid cancer
- endometrium tumor
- nongoitrous congenital hypothyroidism type 2
- lung cancer
- familial adenomatous polyposis
role in cell
- activation in
- cell death
- expression in
- apoptosis
- proliferation
- number
- function
- differentiation
- abnormal morphology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pax8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pronephric field specification
- anatomical structure development
- negative regulation of mesenchymal cell apoptotic process involved in metanephros development
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process involved in metanephric collecting duct development
- negative regulation of apoptotic process involved in metanephric nephron tubule development
- metanephric S-shaped body morphogenesis
- cellular response to gonadotropin stimulus
- metanephric nephron tubule formation
- kidney development
- positive regulation of transcription, DNA-dependent
- mesonephros development
- metanephric distal convoluted tubule development
- negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis
- positive regulation of thyroid hormone generation
- otic vesicle development
- regulation of thyroid-stimulating hormone secretion
- positive regulation of metanephric DCT cell differentiation
- regulation of metanephric nephron tubule epithelial cell differentiation
- metanephric epithelium development
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- sulfur compound metabolic process
- transcription, DNA-dependent
- ventricular septum development
- regulation of apoptotic process
- regulation of transcription from RNA polymerase II promoter
- pronephros development
- positive regulation of branching involved in ureteric bud morphogenesis
- mesenchymal to epithelial transition involved in metanephros morphogenesis
- thyroid gland development
- central nervous system development
- urogenital system development
- metanephric comma-shaped body morphogenesis
- branching involved in ureteric bud morphogenesis
- inner ear morphogenesis
- negative regulation of cardiac muscle cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- thyroid-stimulating hormone receptor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity