Bag2 Gene Summary [Rat]
Predicted to enable several functions, including adenyl-nucleotide exchange factor activity; tau protein binding activity; and transmembrane transporter binding activity. Predicted to be involved in protein stabilization and regulation of protein metabolic process. Predicted to be located in axon and dendritic microtubule. Predicted to be part of protein folding chaperone complex. Orthologous to human BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bag2 |
| Official Name | Bcl2-associated athanogene 2 [Source:RGD Symbol;Acc:1585173] |
| Ensembl ID | ENSRNOG00000012709 |
| Bio databases IDs | |
| Aliases | Bcl2-associated athanogene 2 |
| Synonyms | 2610042A13Rik, BAG cochaperone 2, BCL2-associated athanogene 2, dJ417I1.2, LOC679102 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bag2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenyl-nucleotide exchange factor
- BAG domains, present in regulator of Hsp70 proteins
- tau protein binding
- heat shock protein binding
- ion channel binding
- protein binding
- chaperone binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lymphoma
- androgenic alopecia
- lymphomagenesis
- organismal death
- hepatocellular carcinoma
- liver cancer
role in cell
- apoptosis
- degradation in
- production in
- viability
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Extracellular Space
- Nucleus
- Mitochondria
- microtubules
- cytosol
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bag2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- positive regulation of protein processing
- negative regulation of protein ubiquitination
- protein folding
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein stabilization
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- tau protein binding
- chaperone binding
- adenyl-nucleotide exchange factor activity
- ion channel binding