Phf19 Gene Summary [Rat]
Predicted to enable DNA binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in negative regulation of macromolecule biosynthetic process; stem cell differentiation; and stem cell population maintenance. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human PHF19 (PHD finger protein 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf19 |
| Official Name | PHD finger protein 19 [Source:RGD Symbol;Acc:1310390] |
| Ensembl ID | ENSRNOG00000018874 |
| Bio databases IDs | |
| Aliases | PHD finger protein 19 |
| Synonyms | 3110009G19Rik, 3321402G02RIK, MTF2L1, PCL3, PHD finger protein 19, TDRD19B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phf19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Polycomb-like MTF2 factor 2
- PHD zinc finger
- histone binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding activity, bridging
- PHD finger superfamily
- protein binding
- Tudor domain superfamily
- Jumonji domain-containing protein 2A Tudor domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- rheumatoid arthritis
- skin neoplasm
- skin neoplasia
- organismal death
- colorectal neoplasia
- lung neoplasm
- colon neoplasm
- uterine neoplasm
role in cell
- number
- differentiation
- function
- repression in
- trimethylation in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phf19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression, epigenetic
- stem cell maintenance
- stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- ESC/E(Z) complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- methylated histone residue binding
- chromatin binding