Ctrb1 Gene Summary [Rat]
Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of apoptotic process; response to food; and response to peptide hormone. Predicted to be located in extracellular region. Biomarker of pancreatitis. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctrb1 |
| Official Name | chymotrypsinogen B1 [Source:RGD Symbol;Acc:2444] |
| Ensembl ID | ENSRNOG00000019068 |
| Bio databases IDs | |
| Aliases | chymotrypsinogen B1 |
| Synonyms | 2200008D09Rik, Chymotrypsin, Chymotrypsinogen B, chymotrypsinogen B1, Ctrb, LOC687247, Prt-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- serine-type peptidase
- peptidase
- protein binding
- chymotrypsin
Pathways
Biological processes and signaling networks where the Ctrb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum buds