Zmynd8 Gene Summary [Rat]
Predicted to enable several functions, including histone binding activity; transcription corepressor activity; and zinc ion binding activity. Involved in several processes, including positive regulation of dendritic spine development; positive regulation of filopodium assembly; and regulation of postsynapse organization. Located in dendritic shaft and dendritic spine. Orthologous to human ZMYND8 (zinc finger MYND-type containing 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zmynd8 |
| Official Name | zinc finger, MYND-type containing 8 [Source:RGD Symbol;Acc:1309544] |
| Ensembl ID | ENSRNOG00000019154 |
| Bio databases IDs | |
| Aliases | zinc finger, MYND-type containing 8 |
| Synonyms | 1110013E22Rik, 2010005I16Rik, 3632413B07RIK, AL024039, PKC binding protein 1, PRKCBP1, PRO2893, protein KINASE C binding protein 1, RACK7, spikar, zinc finger MYND-type containing 8, zinc finger, MYND-type containing 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zmynd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- MYND finger
- transcription co-repressor
- protein binding activity, bridging
- PWWP domain
- transcription factor binding
- PWWP (Pro-Trp-Trp-Pro) domain
- protein domain specific binding
- protein binding
- Bromodomain
- Protein kinase C-binding protein 1
- zinc ion binding
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- Huntington disease
- major depression
- neuroticism
- neurodevelopmental disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- insomnia
- depressive disorder
- psoriatic arthritis
regulated by
- lipopolysaccharide
- curcumin
- STK3
- glutamine
- trichostatin A
- topotecan
- metronidazole
- kanamycin A
- vancomycin
- colistin
role in cell
- expression in
- cell viability
- growth
- migration
- assembly
- phagocytosis
- josamycin sensitivity
- missegregation
- development
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- nucleoplasm
- nucleoli
- dendritic spines
- chromatin
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zmynd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- protein localization to chromatin
- nervous system development
- positive regulation of filopodium assembly
- double-strand break repair via homologous recombination
- positive regulation of dendritic spine development
- chromatin organization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- dendritic shaft
- dendritic spine
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- zinc ion binding
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- histone acetyl-lysine binding