Syt3 Gene Summary [Rat]
Enables clathrin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in positive regulation of vesicle fusion; regulation of calcium ion-dependent exocytosis; and response to calcium ion. Is active in synaptic membrane. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt3 |
| Official Name | synaptotagmin 3 [Source:RGD Symbol;Acc:3805] |
| Ensembl ID | ENSRNOG00000019318 |
| Bio databases IDs | |
| Aliases | synaptotagmin 3 |
| Synonyms | SIII, SYNAPTOTAGMIN 3, synaptotagmin III, SytIII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- calcium ion binding
- calcium-dependent phospholipid binding
- clathrin binding
- protein binding
- identical protein binding
- syntaxin binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization
- Protein kinase C conserved region 2 (CalB)
- protein heterodimerization
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- granules
- synaptic membrane
- synaptic vesicles
- dense-core vesicles
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- transport vesicle membrane
- endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding