Egfl7 Gene Summary [Rat]
Predicted to enable Notch binding activity. Predicted to be involved in vasculogenesis. Predicted to act upstream of or within negative regulation of Notch signaling pathway; negative regulation of smooth muscle cell migration; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular space. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Egfl7 |
| Official Name | EGF-like-domain, multiple 7 [Source:RGD Symbol;Acc:708507] |
| Ensembl ID | ENSRNOG00000019388 |
| Bio databases IDs | |
| Aliases | EGF-like-domain, multiple 7 |
| Synonyms | EGF-like domain 7, EGF like domain multiple 7, EGF-like-domain, multiple 7, LOC245963, NEU1, NOTCH4-like, VE-STATIN, ZNEU1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Egfl7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EMI domain
- protein binding
- Coagulation Factor Xa inhibitory site
- EGF_CA
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- central nervous system cancer
- androgenic alopecia
- lung metastasis
- preeclampsia
- Klinefelter syndrome
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
role in cell
- proliferation
- aggregation
- expression in
- formation
- adhesion
- migration
- organization
- migration by
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basal compartment
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Egfl7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood vessel development
- angiogenesis
- anatomical structure development
- cell adhesion
- vasculogenesis
- positive regulation of endothelial cell proliferation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- receptor binding