Spint2 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spint2 |
| Official Name | serine peptidase inhibitor, Kunitz type, 2 [Source:RGD Symbol;Acc:735123] |
| Ensembl ID | ENSRNOG00000020636 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor, Kunitz type, 2 |
| Synonyms | AL024025, DIAR3, HAI-2, Kop, LOC100130414, PB, serine peptidase inhibitor, Kunitz type 2, serine peptidase inhibitor, Kunitz type, 2, Serine protease inhibitor 2, serine protease inhibitor, Kunitz type 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spint2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- serine protease inhibitor activity
- Kunitz protease inhibitor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- epithelial neoplasia
- cancer
- epithelial cancer
- skin neoplasia
- syndromic congenital secretory sodium diarrhea type 3
- prostate cancer
- endometriosis
- prostatic carcinoma
- clear-cell ovarian carcinoma
role in cell
- apoptosis
- growth
- production in
- infiltration by
- phosphorylation in
- molecular cleavage in
- proliferation
- shedding in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- apical cell surfaces
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spint2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell morphogenesis involved in placental branching
- neural tube closure
- cellular response to BMP stimulus
- negative regulation of cell-cell adhesion
- establishment or maintenance of cell polarity
- negative regulation of cell motility
- negative regulation of neural precursor cell proliferation
- basement membrane organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity