Psd Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in maintenance of postsynaptic density structure; neuron differentiation; and regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psd |
| Official Name | pleckstrin and Sec7 domain containing [Source:RGD Symbol;Acc:620297] |
| Ensembl ID | ENSRNOG00000019435 |
| Bio databases IDs | |
| Aliases | pleckstrin and Sec7 domain containing |
| Synonyms | 1110007H17RIK, A930015K15, AI426354, EFA6, EFA6A, mKIAA2011, pleckstrin and Sec7 domain containing, PSD1, PSDL, TYL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- transporter
- purine nucleotide transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- endosomes
- membrane ruffles
- dendritic spines
- cleavage furrow
- postsynaptic density
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- signal transduction
- regulation of ARF protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- dendritic spine
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- phospholipid binding