Smtn Gene Summary [Rat]
Predicted to act upstream of or within negative regulation of systemic arterial blood pressure and positive regulation of cardiac muscle contraction. Orthologous to human SMTN (smoothelin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smtn |
| Official Name | smoothelin [Source:RGD Symbol;Acc:1310216] |
| Ensembl ID | ENSRNOG00000019451 |
| Bio databases IDs | |
| Aliases | smoothelin |
| Synonyms | LOC103690128, smoothelin, smsmo |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smtn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Smoothelin cytoskeleton protein
- structural constituent of muscle
- Calponin homology domain
- actin binding
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- uterine serous papillary cancer
- cardiac hypertrophy
- sepsis
- endometrial cancer
- Huntington disease
- infertility condition
- growth failure
- urinary urgency
- chronic obstructive pulmonary disease
role in cell
- abnormal morphology
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoskeleton
- Cytoplasm
- actin cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smtn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- smooth muscle contraction
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- microtubule organizing center
- cytoplasm
- actin cytoskeleton
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- actin binding