Fli1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fli1 |
| Official Name | Fli-1 proto-oncogene, ETS transcription factor [Source:RGD Symbol;Acc:1309837] |
| Ensembl ID | ENSRNOG00000008904 |
| Bio databases IDs | |
| Aliases | Fli-1 proto-oncogene, ETS transcription factor |
| Synonyms | BDPLT21, EWSR2, Fli-1 proto-oncogene, ETS transcription factor, Friend leukaemia integration 1, Friend leukemia integration 1, LOC100910769, SIC-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fli1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- transcription factor binding domain
- DNA binding domain
- nucleic acid binding
- SAM (Sterile alpha motif )
- transcription activation domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- double-stranded DNA binding
- Ets-domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- rheumatoid arthritis
- prostate cancer
- proteinuria
- bleeding
- tumorigenesis
- hyperplasia
- systemic lupus erythematosus
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- quantity
- transcription in
- apoptosis
- survival
- proliferation
- activation in
- binding in
- phosphorylation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fli1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- megakaryocyte development
- cell differentiation
- blood circulation
- positive regulation of transcription from RNA polymerase II promoter
- hemostasis
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity