Il10ra Gene Summary [Rat]
Enables interleukin-10 binding activity and interleukin-10 receptor activity. Involved in regulation of synapse organization and response to lipopolysaccharide. Predicted to be located in cilium; cytosol; and nucleoplasm. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il10ra |
| Official Name | interleukin 10 receptor subunit alpha [Source:RGD Symbol;Acc:620138] |
| Ensembl ID | ENSRNOG00000016308 |
| Bio databases IDs | |
| Aliases | interleukin 10 receptor subunit alpha |
| Synonyms | CD210, CD210a, CDw210, CDW210A, HIL-10R, IL10R, IL-10R1, IL-10 R alpha, IL-10 R α, interleukin 10 receptor, alpha, interleukin 10 receptor subunit alpha, interleukin 10 receptor subunit α, interleukin 10 receptor, α, mIL-10R |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il10ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- interleukin-10 receptor
- interleukin-10 binding
- intracellular domain
- protein binding
- JAK1bd_box_IFNLR1-like
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il10ra gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- dextran sodium sulfate-induced colitis
- obesity
- insulin-dependent diabetes mellitus
- organismal death
- Crohn disease
- autosomal recessive inflammatory bowel disease type 28
- chronic fatigue syndrome
- colorectal cancer
- rheumatoid arthritis
role in cell
- expression in
- differentiation
- proliferation
- accumulation
- activation in
- killing
- production in
- migration
- growth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- intracellular space
- cellular membrane
- cytosol
- apical membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il10ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent endocytosis
- regulation of synapse organization
- intestinal epithelial structure maintenance
- negative regulation of inflammatory response
- negative regulation of autophagy
- cytokine-mediated signaling pathway
- response to lipopolysaccharide
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-10 receptor activity
- protein binding
- interleukin-10 binding
- signaling receptor activity