Agap1 Gene Summary [Rat]
Predicted to enable GTPase activator activity; GTPase activity; and phospholipid binding activity. Involved in regulation of modification of postsynaptic structure. Is active in postsynaptic endosome. Orthologous to human AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agap1 |
| Official Name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [Source:RGD Symbol;Acc:1309244] |
| Ensembl ID | ENSRNOG00000019476 |
| Bio databases IDs | |
| Aliases | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
| Synonyms | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1, CENTG2, cnt-g2, GGAP1, mKIAA1099 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Ankyrin repeats (many copies)
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Ankyrin repeats (3 copies)
- GTPase
- enzyme
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Ankyrin repeat
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- Putative GTP-ase activating proteins for the small GTPase, ARF
- Rab subfamily of small GTPases
- PH domain
- Ras of Complex, Roc, domain of DAPkinase
- Putative GTPase activating protein for Arf
- P-loop containing Nucleoside Triphosphate Hydrolases
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Goldenhar syndrome
- Parkinson disease
- insomnia
- coronary artery disease
- cardiovascular disorder
- osteoarthritis
- metabolic syndrome X
- COVID-19
- Alzheimer disease
role in cell
- formation
- quantity
- distribution in
- recycling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- endosomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- GTPase activator activity
- phospholipid binding