Aspa Gene Summary [Rat]
Enables identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Used to study Canavan disease and essential tremor. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aspa |
| Official Name | aspartoacylase [Source:RGD Symbol;Acc:621693] |
| Ensembl ID | ENSRNOG00000019659 |
| Bio databases IDs | |
| Aliases | aspartoacylase |
| Synonyms | ACY2, ASP, aspartoacylase, nur7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aspa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Succinylglutamate desuccinylase / Aspartoacylase family
- aminoacylase
- aspartoacylase
- enzyme
- protein binding
- M14 family of metallocarboxypeptidases and related proteins
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- mild Canavan disease
- hereditary disorder
- hepatocellular carcinoma
- Canavan disease
- prion disease
- diabetic nephropathy
- prostatic adenocarcinoma
role in cell
- number
- proliferation
- phosphorylation in
- growth
- differentiation
- invasion by
- migration
- degeneration
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aspa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetate metabolic process
- central nervous system myelination
- aspartate metabolic process
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- identical protein binding
- protein binding
- aspartoacylase activity
- metal ion binding