Diaph1 Gene Summary [Rat]
Predicted to enable several functions, including profilin binding activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in positive regulation of cell migration. Predicted to be located in several cellular components, including brush border; ruffle membrane; and spindle. Predicted to be active in actin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 1 and sensorineural hearing loss. Orthologous to human DIAPH1 (diaphanous related formin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Diaph1 |
| Official Name | diaphanous-related formin 1 [Source:RGD Symbol;Acc:1310707] |
| Ensembl ID | ENSRNOG00000019688 |
| Bio databases IDs | |
| Aliases | diaphanous-related formin 1 |
| Synonyms | BC012974, D18Wsu154e, DFNA1, DIA1, DIAP1, Diap1 (predicted), diaphanous-related formin 1, DRF1, hDIA1, LFHL1, MDIA1, p140mDia, SCBMS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Diaph1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- GTPase binding domain
- Diaphanous FH3 Domain
- RhoA binding domain
- diaphanous autoregulatory domain
- enzyme binding
- protein binding
- formin homology domain 3
- identical protein binding
- proline rich domain
- Diaphanous GTPase-binding Domain
- profilin binding
- formin homology domain 1
- Diaphanous inhibitory domain
- actin binding
- ion channel binding
- dia-autoinhibitory domain
- Rho-binding domain
Pathways
Biological processes and signaling networks where the Diaph1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatological disorder
- organismal death
- allergy
- lymphopenia
- echinocytosis
- systemic lupus erythematosus
- pancreatic epithelial cancer
- pancreatic adenocarcinoma
- colon carcinoma
- colon epithelial cancer
role in cell
- phosphorylation in
- formation
- formation in
- expression in
- proliferation
- damage in
- stabilization in
- quantity
- cell cycle progression
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- Nucleus
- secretory granule membrane
- cytosol
- membrane ruffles
- spindle fibers
- growth cone
- neurites
- membrane blebs
- brush border
- cleavage furrow
- filopodia
- mitotic spindle
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Diaph1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of release of sequestered calcium ion into cytosol
- regulation of cell shape
- cytoskeleton organization
- cellular response to histamine
- regulation of cytoskeleton organization
- protein localization to microtubule
- actin filament polymerization
- actin cytoskeleton organization
- regulation of microtubule-based process
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- nucleus
- centrosome
- mitotic spindle
- cytoplasm
- cytosol
- ruffle membrane
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- actin binding
- small GTPase binding
- ion channel binding
- receptor binding