St3gal3 Gene Summary [Rat]
Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process via lactosylceramide and protein glycosylation. Predicted to be located in Golgi cisterna membrane; Golgi membrane; and extracellular region. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 12 and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal3 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [Source:RGD Symbol;Acc:68414] |
| Ensembl ID | ENSRNOG00000019843 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
| Synonyms | DEE15, EIEE15, MRT12, Siat3, SIAT6, ST3 beta-galactoside alpha-2,3-sialyltransferase 3, ST3GALII, ST3Gal III, ST3N, ST3 β-galactoside α-2,3-sialyltransferase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat St3gal3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- sialyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- coronary artery disease
- Ohtahara syndrome
- schizophrenia
- autosomal recessive mental retardation type 12
- attention deficit hyperactivity disorder
- hereditary disorder
- early infantile epileptic encephalopathy type 15
- nonlobar intracerebral hemorrhage
- amyotrophic lateral sclerosis
regulates
- oligosaccharide
- glycosphingolipid
- sialyl 6-sulfo Lewis X
- Alpha1-3-gt
- O-glycan
- keratan sulfate
role in cell
- apoptosis
- antigenicity
- reverse transcription
- reverse transcription in
- cytolysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat St3gal3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ganglioside biosynthetic process via lactosylceramide
- viral protein processing
- protein glycosylation
- oligosaccharide biosynthetic process
- keratan sulfate biosynthetic process
- O-glycan processing
- glycosphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- N-acetyllactosaminide alpha-2,3-sialyltransferase activity