Klhl17 Gene Summary [Rat]
Enables POZ domain binding activity; actin filament binding activity; and molecular adaptor activity. Involved in actin cytoskeleton organization and regulation protein catabolic process at postsynapse. Located in actin cytoskeleton; dendrite cytoplasm; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl17 |
| Official Name | kelch-like family member 17 [Source:RGD Symbol;Acc:708444] |
| Ensembl ID | ENSRNOG00000020302 |
| Bio databases IDs | |
| Aliases | kelch-like family member 17 |
| Synonyms | AF, AL022703, kelch-like 17, kelch-like family member 17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klhl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein domain specific binding
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- actin cytoskeleton
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klhl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular space
- dendrite cytoplasm
- actin cytoskeleton
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- POZ domain binding
- protein binding
- binding, bridging