KLHL17 Gene Summary [Human]
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | KLHL17 |
| Official Name | kelch like family member 17 [Source:HGNC Symbol;Acc:HGNC:24023] |
| Ensembl ID | ENSG00000187961 |
| Bio databases IDs | |
| Aliases | kelch like family member 17, actinfilin |
| Synonyms | AF, AL022703, kelch-like 17, kelch-like family member 17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein domain specific binding
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- actin cytoskeleton
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular space
- dendrite cytoplasm
- actin cytoskeleton
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- POZ domain binding
- protein binding
- binding, bridging