Tkfc Gene Summary [Rat]
Enables triokinase activity. Predicted to be involved in carbohydrate catabolic process; carbohydrate phosphorylation; and negative regulation of MDA-5 signaling pathway. Is active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tkfc |
| Official Name | triokinase and FMN cyclase [Source:RGD Symbol;Acc:1311026] |
| Ensembl ID | ENSRNOG00000020704 |
| Bio databases IDs | |
| Aliases | triokinase and FMN cyclase |
| Synonyms | BC021917, DAK, DKFZP586B1621, NET45, RGD1311026, TKFCD, triokinase and FMN cyclase, triokinase, FMN cyclase, Triose kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tkfc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- dihydroxyacetone kinase, ATP-dependent
- PRK14479
- glycerone kinase
- ATP-binding domain
- triokinase
- cyclase
- DAK2 domain
- protein binding
- Dak1 domain
- PRK14481
- phosphorus-oxygen lyase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- triokinase and FMN cyclase deficiency syndrome
- liver cancer
- hepatocellular carcinoma
regulates
- carbohydrate
- IFNB1
role in cell
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tkfc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- negative regulation of MDA-5 signaling pathway
- regulation of innate immune response
- glycerol catabolic process
- carbohydrate phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- triokinase activity
- ATP binding
- protein binding
- FAD-AMP lyase (cyclizing) activity
- metal ion binding
- glycerone kinase activity