Klhl17 Gene Summary [Mouse]
Predicted to enable POZ domain binding activity; actin filament binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in actin cytoskeleton organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation protein catabolic process at postsynapse. Predicted to be located in actin cytoskeleton; dendrite cytoplasm; and neuronal cell body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl17 |
| Official Name | kelch-like 17 [Source:NCBI gene (formerly Entrezgene);Acc:231003] |
| Ensembl ID | ENSMUSG00002076083 |
| Bio databases IDs | |
| Aliases | kelch-like 17 |
| Synonyms | AF, AL022703, kelch-like 17, kelch-like family member 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein domain specific binding
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- actin cytoskeleton
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular space
- dendrite cytoplasm
- actin cytoskeleton
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- POZ domain binding
- protein binding
- binding, bridging