Wdr11 Gene Summary [Rat]
Predicted to be involved in several processes, including cilium assembly; regulation of smoothened signaling pathway; and vesicle tethering to Golgi. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and trans-Golgi network. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder and hypogonadotropic hypogonadism 14 with or without anosmia. Orthologous to human WDR11 (WD repeat domain 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr11 |
| Official Name | WD repeat domain 11 [Source:RGD Symbol;Acc:1587347] |
| Ensembl ID | ENSRNOG00000020430 |
| Bio databases IDs | |
| Aliases | WD repeat domain 11 |
| Synonyms | 2900055P10Rik, BRWD2, DR11, HH14, mKIAA1351, SRI1, WDR15, WD repeat domain 11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- anorexia nervosa
- autosomal recessive intellectual developmental disorder type 78
- microcephaly
- idiopathic hypogonadotropic hypogonadism
- hypoplasia
- benign prostatic hyperplasia
- hypogonadotropic hypogonadism 14
- hypogonadotropic hypogonadism 14 without anosmia
- hypotelorism
regulated by
- purmorphamine
- KLF3
role in cell
- expression in
- number
- assembly
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- Nucleus
- Plasma Membrane
- basal bodies
- axonemes
- cytosol
- trans Golgi network
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- heart development
- head development
- cilium morphogenesis
- intracellular protein transport
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- trans-Golgi network
- cilium basal body
- cytoplasm
- membrane
- cytosol
- cytoplasmic vesicle
- lysosomal membrane
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding