Wdr11 Gene Summary [Mouse]
Involved in several processes, including cilium assembly; heart development; and regulation of smoothened signaling pathway. Located in axoneme; ciliary basal body; and nucleus. Is expressed in several structures, including central nervous system; frontal bone primordium; metanephros; otic capsule; and submandibular gland primordium. Used to study Kallmann syndrome and ciliopathy. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder and hypogonadotropic hypogonadism 14 with or without anosmia. Orthologous to human WDR11 (WD repeat domain 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr11 |
| Official Name | WD repeat domain 11 [Source:MGI Symbol;Acc:MGI:1920230] |
| Ensembl ID | ENSMUSG00000042055 |
| Bio databases IDs | |
| Aliases | WD repeat domain 11 |
| Synonyms | 2900055P10Rik, BRWD2, DR11, HH14, mKIAA1351, SRI1, WDR15, WD repeat domain 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- purmorphamine
- KLF3
disease
- schizophrenia
- anorexia nervosa
- autosomal recessive intellectual developmental disorder type 78
- microcephaly
- idiopathic hypogonadotropic hypogonadism
- hypoplasia
- benign prostatic hyperplasia
- hypogonadotropic hypogonadism 14
- hypogonadotropic hypogonadism 14 without anosmia
- hypotelorism
phenotypes
- abnormal bone structure
- abnormal eye morphology
- abnormal freezing behavior
- abnormal heart morphology
- abnormal kidney morphology
- abnormal liver morphology
- abnormal skin morphology
- abnormal spinal cord morphology
- absent seminal vesicle
- anophthalmia
- decreased blood urea nitrogen level
- decreased body length
- decreased circulating alanine transaminase level
- enlarged heart
- enlarged kidney
- enlarged seminal vesicle
- improved glucose tolerance
- increased red blood cell distribution width
- iris synechia
- male infertility
- small heart
- Leydig cell hypoplasia
- Rathke's pouch hypoplasia
- abnormal adenohypophysis morphology
- abnormal choroid plexus morphology
- abnormal circulating creatinine level
- abnormal craniofacial morphology
- abnormal embryonic neuroepithelium morphology
- abnormal estrous cycle
- abnormal eye development
- abnormal facial morphology
- abnormal forebrain morphology
- abnormal hypothalamus physiology
- abnormal medial nasal prominence morphology
- abnormal midface morphology
- abnormal nasal pit morphology
- abnormal neurohypophysis median eminence morphology
- abnormal neuronal migration
- abnormal nose morphology
- abnormal olfactory bulb development
- abnormal olfactory epithelium cilium morphology
- abnormal optic eminence morphology
- abnormal pituitary diverticulum morphology
- abnormal pituitary gland development
- abnormal primary cilium morphology
- abnormal red blood cell distribution width
- abnormal respiratory conducting tube morphology
- abnormal skeleton morphology
- abnormal thoracic cage morphology
- abnormal uterus morphology
- absent adrenal gland
- absent corpus luteum
- absent secondary ovarian follicles
- cyclopia
- decreased bone mineralization
- decreased neuron number
- decreased survivor rate
- delayed balanopreputial separation
- delayed sexual maturation
- double outlet right ventricle
- embryonic growth retardation
- enlarged brain ventricles
- exencephaly
- external male genitalia hypoplasia
- holoprosencephaly
- hydrocephaly
- impaired ovarian folliculogenesis
- increased body mass index
- increased liver weight
- increased percent body fat/body weight
- lethality throughout fetal growth and development incomplete penetrance
- microcephaly
- microvesicular hepatic steatosis
- nasal septum hypoplasia
- obese
- ocular hypotelorism
- olfactory bulb hypoplasia
- ovary cysts
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- protruding tongue
- reduced male fertility
- seminiferous tubule degeneration
- short limbs
- short perineum
- small mandible
- small ovary
- small penis
- small testis
- small uterus
- syndactyly
- teratozoospermia
- ventricular septal defect
role in cell
- expression in
- number
- assembly
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- Nucleus
- Plasma Membrane
- basal bodies
- axonemes
- cytosol
- trans Golgi network
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- heart development
- head development
- cilium morphogenesis
- intracellular protein transport
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- trans-Golgi network
- cilium basal body
- cytoplasm
- membrane
- cytosol
- cytoplasmic vesicle
- lysosomal membrane
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding