Sox6 Gene Summary [Rat]
Enables cis-regulatory region sequence-specific DNA binding activity. Involved in astrocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox6 |
| Official Name | SRY-box transcription factor 6 [Source:RGD Symbol;Acc:1309000] |
| Ensembl ID | ENSRNOG00000020514 |
| Bio databases IDs | |
| Aliases | SRY-box transcription factor 6 |
| Synonyms | HSSOX6, LOC102549121, SOXD, SOX-LZ, SRY-box transcription factor 6, SRY (sex determining region Y)-box 6, TOLCAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sox6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- HMG (high mobility group) box
- HMG-box domain
- polyglutamine repeat
- high mobility group
- protein homodimerization
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sox6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immune thrombocytopenia
- fracture of bone
- epithelial cancer
- obesity
- hypertension
- major depression
- colorectal cancer
- osteoporosis
- Tolchin-Le Caignec syndrome
- sunburn
role in cell
- activation in
- cell death
- expression in
- proliferation
- apoptosis
- differentiation
- morphology
- inhibition in
- transcription in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sox6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cartilage development
- spinal cord oligodendrocyte cell differentiation
- chondrocyte differentiation
- regulation of transcription, DNA-dependent
- brain development
- regulation of transcription from RNA polymerase II promoter
- muscle organ development
- cellular response to transforming growth factor beta stimulus
- central nervous system development
- cartilage condensation
- negative regulation of transcription, DNA-dependent
- negative regulation of cardiac muscle cell differentiation
- cell fate commitment
- positive regulation of mesenchymal stem cell differentiation
- positive regulation of chondrocyte differentiation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity