Rpl27 Gene Summary [Rat]
Predicted to be a structural constituent of ribosome. Involved in response to aldosterone. Located in ribosome. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 16. Orthologous to human RPL27 (ribosomal protein L27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl27 |
| Official Name | ribosomal protein L27 [Source:RGD Symbol;Acc:621192] |
| Ensembl ID | ENSRNOG00000020674 |
| Bio databases IDs | |
| Aliases | ribosomal protein L27 |
| Synonyms | DBA16, eL27, L27, ribosomal protein L27, RL27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- Ribosomal L27e protein family
- protein binding
Pathways
Biological processes and signaling networks where the Rpl27 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- recurrent implantation failure
- Diamond-Blackfan anemia type 16
- non-small cell lung carcinoma
- non-small cell lung cancer
- leiomyoma
- leiomyomatosis
- preeclampsia
role in cell
- cell death
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosolic large ribosomal subunit
- synapse
- nucleolus
- ribosome
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome