Ifi35 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in several cellular components, including cytosol; extracellular space; and nuclear lumen. Predicted to be active in nucleus. Orthologous to human IFI35 (interferon induced protein 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifi35 |
| Official Name | interferon-induced protein 35 [Source:RGD Symbol;Acc:1304553] |
| Ensembl ID | ENSRNOG00000020678 |
| Bio databases IDs | |
| Aliases | interferon-induced protein 35 |
| Synonyms | 2010008K16RIK, IFP35, interferon-induced protein 35, IPF35 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifi35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- Nmi/IFP35 domain
- protein binding
- Interferon-induced 35 kDa protein (IFP 35) N-terminus
- identical protein binding
- Nmi/IFP 35 domain (NID)
Pathways
Biological processes and signaling networks where the Ifi35 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- basal cell skin cancer
- skin cancer
- tuberculosis
- organismal death
- Sjogren syndrome keratoconjunctivitis sicca
- systemic lupus erythematosus
- spinal cord demyelination
- colorectal cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- multiple sclerosis
role in cell
- proliferation
- expression in
- number
- activation
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Extracellular Space
- cellular membrane
- granules
- cytosol
- nucleoplasm
- nucleoli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifi35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of innate immune response
- negative regulation of cell proliferation
- innate immune response
- positive regulation of inflammatory response
- macrophage activation involved in immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding