Bag6 Gene Summary [Rat]
Predicted to enable several functions, including Hsp70 protein binding activity; enzyme binding activity; and misfolded protein binding activity. Involved in regulation of cell population proliferation. Predicted to be located in several cellular components, including cytosol; extracellular exosome; and nucleoplasm. Predicted to be part of BAT3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bag6 |
| Official Name | BCL2-associated athanogene 6 [Source:RGD Symbol;Acc:71064] |
| Ensembl ID | ENSRNOG00000000851 |
| Bio databases IDs | |
| Aliases | BCL2-associated athanogene 6 |
| Synonyms | 2410045D21Rik, AA408914, BAG cochaperone 6, BAT3, BCL2-associated athanogene 6, D17H6S52E, D6S52E, G3, Scythe |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bag6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Hsp70 protein binding
- protease binding
- BCL2-associated athanogene 6
- enzyme
- protein binding
- receptor binding
- ubiquitin-like domain
- identical protein binding
- Ubiquitin family
- binding protein
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- ribosome binding
- receptor agonist activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- coronary artery disease
- small cell lung cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- irritable bowel syndrome
- small cell lung carcinoma
- hypoplasia
- respiratory failure
- exencephaly
role in cell
- proliferation
- expression in
- transactivation in
- signaling in
- apoptosis
- activation
- quantity
- shortening
- formation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- nucleoplasm
- late endosomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bag6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- synaptonemal complex assembly
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of proteolysis
- chromatin organization
- posttranslational protein targeting to membrane
- kidney development
- internal peptidyl-lysine acetylation
- apoptotic process
- natural killer cell activation
- lung development
- proteasomal protein catabolic process
- spermatogenesis
- regulation of embryonic development
- brain development
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein stability
- negative regulation of apoptotic process
- immune response-activating cell surface receptor signaling pathway
- cell differentiation
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- protein stabilization
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- BAT3 complex
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proteasome binding
- ubiquitin protein ligase binding
- protein binding
- polyubiquitin binding
- ribosome binding
- receptor binding
- misfolded protein binding
- Hsp70 protein binding
- binding, bridging