Hrc Gene Summary [Rat]
Predicted to enable ATPase binding activity; calcium ion binding activity; and transmembrane transporter binding activity. Involved in negative regulation of calcium ion import into sarcoplasmic reticulum and negative regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including Z disc; mitochondrion; and sarcoplasmic reticulum membrane. Orthologous to human HRC (histidine rich calcium binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hrc |
| Official Name | histidine rich calcium binding protein [Source:RGD Symbol;Acc:727864] |
| Ensembl ID | ENSRNOG00000020719 |
| Bio databases IDs | |
| Aliases | histidine rich calcium binding protein |
| Synonyms | HCP, histidine rich calcium binding protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hrc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- histidine rich acidic repeat
- polyglutamine repeat
- calcium ion binding
- ion channel binding
- protein binding
- cysteine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum lumen
- Z line
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hrc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- regulation of heart rate
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- muscle contraction
- cytosolic calcium ion homeostasis
- regulation of peptidyl-serine phosphorylation
- positive regulation of heart contraction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- Z disc
- endoplasmic reticulum lumen
- sarcoplasmic reticulum lumen
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- ion channel binding
- ATPase binding