Frmd8 Gene Summary [Rat]
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of tumor necrosis factor production. Predicted to act upstream of or within protein localization to plasma membrane. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to several human genes including FRMD8 (FERM domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frmd8 |
| Official Name | FERM domain containing 8 [Source:RGD Symbol;Acc:1310323] |
| Ensembl ID | ENSRNOG00000020881 |
| Bio databases IDs | |
| Aliases | FERM domain containing 8 |
| Synonyms | 1200004M23Rik, 2310035N23Rik, 4931429L16Rik, FERM domain containing 8, FKSG44, iTAP, RGD1310323 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Frmd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Frmd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of tumor necrosis factor production
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding