FRMD8 Gene Summary [Human]
Involved in positive regulation of tumor necrosis factor production. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FRMD8 |
| Official Name | FERM domain containing 8 [Source:HGNC Symbol;Acc:HGNC:25462] |
| Ensembl ID | ENSG00000126391 |
| Bio databases IDs | |
| Aliases | FERM domain containing 8, iRhom Tail-Associated Protein |
| Synonyms | 1200004M23Rik, 2310035N23Rik, 4931429L16Rik, FERM domain containing 8, FKSG44, iTAP, RGD1310323 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRMD8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRMD8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of tumor necrosis factor production
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding