Fut1 Gene Summary [Rat]
Predicted to enable galactoside 2-alpha-L-fucosyltransferase activity. Predicted to be involved in several processes, including positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of sprouting angiogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human FUT1 (fucosyltransferase 1 (H blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fut1 |
| Official Name | fucosyltransferase 1 [Source:RGD Symbol;Acc:2638] |
| Ensembl ID | ENSRNOG00000020995 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 1 |
| Synonyms | fucosyltransferase 1, fucosyltransferase 1 (H blood group), Futa, HH, HSC, MFUT-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fut1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP-fucose protein O-fucosyltransferase and related proteins
- Glycosyl transferase family 11
- galactoside 2-alpha-L-fucosyltransferase
- fucosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- inflammatory bowel disease
role in cell
- proliferation
- activation in
- binding
- migration
- apoptosis
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fut1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of cell-matrix adhesion
- fucosylation
- protein glycosylation
- regulation of endothelial cell proliferation
- oligosaccharide biosynthetic process
- L-fucose catabolic process
- regulation of cell adhesion
- glycosphingolipid biosynthetic process
- olfactory bulb development
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- fucosyltransferase activity
- alpha-(1,2)-fucosyltransferase activity
- galactoside 2-alpha-L-fucosyltransferase activity