Ndufb3 Gene Summary [Rat]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 25. Orthologous to human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufb3 |
| Official Name | NADH:ubiquinone oxidoreductase subunit B3 [Source:RGD Symbol;Acc:1310737] |
| Ensembl ID | ENSRNOG00000011825 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit B3 |
| Synonyms | 2700033I16Rik, B12, CI-B12, MC1DN25, NADH:ubiquinone oxidoreductase subunit B3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH-ubiquinone oxidoreductase B12 subunit family
- enzyme
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Ndufb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- Huntington disease
- hereditary disorder
- septic shock
- nuclear type 25 mitochondrial complex I deficiency
- mitochondrial disorder
- Mitochondrial complex I deficiency
- adult acute myeloid leukemia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity