Cdkn1c Gene Summary [Rat]
Predicted to enable protein kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cyclin-dependent protein kinase activity; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic placenta morphogenesis; regulation of gene expression; and uterus development. Predicted to be located in cytoplasm and nucleus. Used to study lung cancer. Biomarker of lung cancer. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn1c |
| Official Name | cyclin-dependent kinase inhibitor 1C [Source:RGD Symbol;Acc:727892] |
| Ensembl ID | ENSRNOG00000059500 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 1C |
| Synonyms | BWCR, BWS, CDK1C, CDKI, CDK INHIBITOR 1C, cyclin-dependent kinase inhibitor 1C, IMAGE, KIP2, p57, p57KIP2, p57(kip2), WBS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdkn1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- QT domain
- PCNA binding domain
- 3-10 helix
- Cki domain
- protein kinase inhibitor activity
- alpha helix
- cdk phosphorylation site
- protein binding
- acidic domain
- proline rich domain
- cyclin-dependent kinase binding domain
- cyclin-CDK binding domain
- binding protein
- cyclin-binding domain
- Cyclin-dependent kinase inhibitor
Pathways
Biological processes and signaling networks where the Cdkn1c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- thrombocytopenia
- psoriasis
- epithelial cancer
- epithelial neoplasia
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
role in cell
- apoptosis
- phosphorylation in
- binding in
- expression in
- proliferation
- quantity
- cell viability
- survival
- accumulation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdkn1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of epithelial cell proliferation
- negative regulation of mitotic cell cycle
- negative regulation of kinase activity
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cyclin-dependent protein kinase inhibitor activity
- protein kinase inhibitor activity