Ttr Gene Summary [Rat]
Enables hormone binding activity. Predicted to be involved in negative regulation of glomerular filtration; purine nucleobase metabolic process; and retinoid metabolic process. Located in extracellular space. Part of protein-containing complex. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttr |
| Official Name | transthyretin [Source:RGD Symbol;Acc:3916] |
| Ensembl ID | ENSRNOG00000016275 |
| Bio databases IDs | |
| Aliases | transthyretin |
| Synonyms | ATTR, CTS, CTS1, HEL111, HsT2651, Lr1, PALB, Prealbumin, TBPA, transthyretin, Transthyretin isomer 1, Transthyretin isomer 2, TT, TTN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- HIUase/Transthyretin family
- binding protein
- Peptidase_M14NE-CP-C_like
- protein binding
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Ttr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- non-insulin-dependent diabetes mellitus
- major depression
- hereditary systemic amyloidosis
- Alzheimer disease
- transthyretin amyloidosis
- Charcot-Marie-Tooth disease
- familial transthyretin amyloidosis
- small cell lung cancer
- first-onset paranoid schizophrenia
role in cell
- migration
- proliferation
- production in
- apoptosis
- expression in
- cell death
- formation
- differentiation
- deposition
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- azurophil granule lumen
- Cytoplasm
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- purine base metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- thyroid hormone binding
- hormone activity