Rassf2 Gene Summary [Rat]
Predicted to enable protein kinase activity. Predicted to be involved in protein stabilization; regulation of intracellular signal transduction; and signal transduction. Predicted to act upstream of or within several processes, including canonical NF-kappaB signal transduction; negative regulation of non-canonical NF-kappaB signal transduction; and regulation of protein phosphorylation. Predicted to be located in several cellular components, including Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RASSF2 (Ras association domain family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rassf2 |
| Official Name | Ras association domain family member 2 [Source:RGD Symbol;Acc:1305551] |
| Ensembl ID | ENSRNOG00000021261 |
| Bio databases IDs | |
| Aliases | Ras association domain family member 2 |
| Synonyms | 3830431H01Rik, 9030412M04Rik, CENP-34, KIAA0168, Ras association domain family member 2, Ras association (RalGDS/AF-6) domain family member 2, RASFADIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rassf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- SARAH_SF
- protein kinase
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- fibrosis
- thoracic aortic aneurysms and dissections
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- growth failure
- hypoplasia
regulates
- NFkB (complex)
- IKK (complex)
- peptide
- PAWR
role in cell
- apoptosis
- colony formation
- number
- differentiation
- ossification by
- abnormal morphology
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rassf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone remodeling
- signal transduction
- I-kappaB kinase/NF-kappaB cascade
- regulation of osteoblast differentiation
- positive regulation of protein autophosphorylation
- skeletal system development
- positive regulation of protein kinase activity
- ossification
- homeostasis of number of cells
- positive regulation of JNK cascade
- regulation of osteoclast differentiation
- positive regulation of apoptotic process
- negative regulation of peptidyl-serine phosphorylation
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- Golgi apparatus
- kinetochore
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase activity