RASSF2 Gene Summary [Human]
This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | RASSF2 |
| Official Name | Ras association domain family member 2 [Source:HGNC Symbol;Acc:HGNC:9883] |
| Ensembl ID | ENSG00000101265 |
| Bio databases IDs | |
| Aliases | Ras association domain family member 2, centromere protein 34 |
| Synonyms | 3830431H01Rik, 9030412M04Rik, CENP-34, KIAA0168, Ras association domain family member 2, Ras association (RalGDS/AF-6) domain family member 2, RASFADIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASSF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- SARAH_SF
- protein kinase
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- fibrosis
- thoracic aortic aneurysms and dissections
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- growth failure
- hypoplasia
regulates
- NFkB (complex)
- IKK (complex)
- peptide
- PAWR
role in cell
- apoptosis
- colony formation
- number
- differentiation
- ossification by
- abnormal morphology
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASSF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone remodeling
- signal transduction
- I-kappaB kinase/NF-kappaB cascade
- regulation of osteoblast differentiation
- positive regulation of protein autophosphorylation
- skeletal system development
- positive regulation of protein kinase activity
- ossification
- homeostasis of number of cells
- positive regulation of JNK cascade
- regulation of osteoclast differentiation
- positive regulation of apoptotic process
- negative regulation of peptidyl-serine phosphorylation
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- Golgi apparatus
- kinetochore
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase activity